Kornilova, S. V. and Miskovsky, P. and Tomkova, A. and Kapinos, L. E. and Hackl, E. V. and Andrushchenko, V. V. and Grigoriev, D. N. and Blagoi, Y. P.. (1997) Vibrational spectroscopic studies of the divalent metal ion effect on DNA structural transitions. Journal of Molecular Structure , 408. pp. 219-223.
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Abstract
Raman spectroscopy is used to study DNA complexes with Cu2+, Mn2+ and Ca2+ ions in 0.001 M NaCl, pH 7.0. The changes observed in the spectra permit us to conclude that all the ions interact both with the DNA phosphate groups and with the nucleic bases, changing the DNA structure. Ca2+ and Mn2+ ions bind to N7 of guanine and adenine only, but Cu2+ ions can probably bind to N7, O6 of guanine and N3 of cytosine as well. The latter type of binding occurs as the base is turning around the glycoside bonds and a G-C pair transition from anti to syn conformation takes place. Besides, at high concentrations of Ca2+ ions a partial B-A transition takes place in DNA.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nanobiology Argovia (Lim) |
|---|---|
| UniBasel Contributors: | Kapinos Schneider, Larisa E. E |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 0022-2860 |
| e-ISSN: | 1872-8014 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: | |
| Last Modified: | 22 Nov 2017 11:12 |
| Deposited On: | 22 Nov 2017 11:12 |
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