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Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I

Scotet, E. and Martinez, L. O. and Grant, E. and Barbaras, R. and Jeno, P. and Guiraud, M. and Monsarrat, B. and Saulquin, X. and Maillet, S. and Esteve, J. P. and Lopez, F. and Perret, B. and Collet, X. and Bonneville, M. and Champagne, E.. (2005) Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I. Immunity, 22 (1). pp. 71-80.

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Official URL: http://edoc.unibas.ch/46908/

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Abstract

Vgamma9Vdelta2 T lymphocytes, a major gammadelta T lymphocyte subset in humans, display cytolytic activity against various tumor cells upon recognition of yet uncharacterized structures. Here, we show that an entity related to the mitochondrial F1-ATPase is expressed on tumor cell surface and promotes tumor recognition by Vgamma9Vdelta2 T cells. When immobilized, purified F1-ATPase induces selective activation of this lymphocyte subset. The Vgamma9Vdelta2 T cell receptors (TCR) and the F1-ATPase also bind a delipidated form of apolipoprotein A-I (apo A-I), as demonstrated by surface plasmon resonance. Moreover, the presence of apo A-I in the culture medium is required for optimal activation of Vgamma9Vdelta2 T cells by tumors expressing F1-ATPase. This study thus describes an unanticipated tumor recognition mechanism by Vgamma9Vdelta2 lymphocytes and a possible link between gammadelta T cell immunity and lipid metabolism.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Mass Spectrometry (Jenö)
UniBasel Contributors:Jenö, Paul
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
ISSN:1074-7613
e-ISSN:1097-4180
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:11 Dec 2017 09:04
Deposited On:11 Dec 2017 09:04

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