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Low-dose dexamethasone suppression test in chronic fatigue syndrome and health

Gaab, Jens and Hüster, Dominik and Peisen, Renate and Engert, Veronika and Schad, Tanja and Schürmeyer, Thomas H. and Ehlert, Ulrike. (2002) Low-dose dexamethasone suppression test in chronic fatigue syndrome and health. Psychosomatic Medicine, 64 (2). pp. 311-318.

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Official URL: http://edoc.unibas.ch/46399/

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Abstract

Subtle dysregulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome have been described. The aim of this study was to examine the negative feedback regulations of the hypothalamus-pituitary-adrenal axis in chronic fatigue syndrome.; In 21 patients with chronic fatigue syndrome and 21 healthy control subjects, awakening and circadian salivary free cortisol profiles were assessed over 2 consecutive days and compared with awakening and circadian salivary free cortisol profiles after administration of 0.5 mg of dexamethasone at 11:00 PM the previous day.; Patients with chronic fatigue syndrome had normal salivary free cortisol profiles but showed enhanced and prolonged suppression of salivary free cortisol after the administration of 0.5 mg of dexamethasone in comparison to the control subjects.; Enhanced negative feedback of the hypothalamus-pituitary-adrenal axis could be a plausible explanation for the previously described alterations in hypothalamus-pituitary-adrenal axis functioning in chronic fatigue syndrome. Because similar changes have been described in stress-related disorders, a putative role of stress in the pathogenesis of the enhanced feedback is possible.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Psychotherapie (Gaab)
UniBasel Contributors:Gaab, Jens
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
ISSN:0033-3174
e-ISSN:1534-7796
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Nov 2017 11:13
Deposited On:23 Nov 2017 11:13

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