Bace2 Is a Beta-Cell-Enriched Protease that Regulates Pancreatic Beta-Cell Function and Mass

Esterházy, Daria and Stützer, Ina and Wang, Haiyan and Rechsteiner, Markus P. and Beauchamp, Jeremy and Döbeli, Heinz and Hilpert, Hans and Matile, Hugues and Prummer, Michael and Schmidt, Alexander and Lieske, Nora and Boehm, Bernhard and Marselli, Lorella and Bosco, Domenico and Kerr-Conte, Julie and Aebersold, Ruedi and Spinas, Giatgen Andreia and Moch, Holger and Migliorini, Cristiano and Stoffel, Markus. (2011) Bace2 Is a Beta-Cell-Enriched Protease that Regulates Pancreatic Beta-Cell Function and Mass. Cell Metabolism, 14 (3). pp. 365-377.

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Decreased ? cell mass and function are hallmarks of type 2 diabetes. Here we identified, through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and human ? cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a newly identified Bace2 inhibitor both display augmented ? cell mass and improved control of glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the control of ? cell maintenance and provide a rational strategy to inhibit this protease for the expansion of functional pancreatic ? cell mass.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Proteomics (Schmidt)
UniBasel Contributors:Schmidt, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Nov 2017 08:00
Deposited On:30 Nov 2017 08:00

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