Ultrasonography of gallbladder abnormalities due to schistosomiasis

Richter, Joachim and Azoulay, Daniel and Dong, Yi and Holtfreter, Martha C. and Akpata, Robert and Calderaro, Julien and El-Scheich, Tarik and Breuer, Matthias and Neumayr, Andreas and Hatz, Christoph and Kircheis, Gerald and Botelho, Monica C. and Dietrich, Christoph F.. (2016) Ultrasonography of gallbladder abnormalities due to schistosomiasis. Parasitology research, 115 (8). pp. 2917-2924.

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Official URL: http://edoc.unibas.ch/44657/

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After malaria, schistosomiasis remains the most important tropical parasitic disease in large parts of the world. Schistosomiasis has recently re-emerged in Southern Europe. Intestinal schistosomiasis is caused by most Schistosoma (S.) spp. pathogenic to humans and leads to chronic inflammation and fibrosis of the colon as well as to liver fibrosis. Gallbladder abnormalities usually occur in patients with advanced hepatic portal fibrosis due to Schistosoma mansoni infection. Occasionally, gallbladder abnormalities have been seen also in children and occurring without associated overt liver abnormalities.The specific S. mansoni-induced gallbladder abnormalities detectable by ultrasound include typical hyperechogenic wall thickening with external gallbladder wall protuberances. The luminal wall surface is smooth. The condition is usually clinically silent although some cases of symptomatic cholecystitis have been described. The ultrasonographic Murphy response is negative. Gallbladder contractility is impaired but sludge and calculi occur rarely. Contrary to other trematodes such as liver flukes, S. mansoni does not obstruct the biliary tract. Advanced gallbladder fibrosis is unlikely to reverse after therapy.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Medicines Development (Paris)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Medicines Development (Paris)
UniBasel Contributors:Hatz, Christoph and Neumayr, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Dec 2016 10:55
Deposited On:06 Dec 2016 08:02

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