Role for coronin 1 in mouse NK cell function

Tchang, Vincent Sam Yong and Stiess, Michael and Siegmund, Kerstin and Karrer, Urs and Pieters, Jean. (2017) Role for coronin 1 in mouse NK cell function. Immunobiology : Experimental and Clinical , 222 (2). pp. 291-300.

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Official URL: http://edoc.unibas.ch/44573/

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Coronin 1, a member of the evolutionary conserved WD repeat protein family of coronin proteins is expressed in all leukocytes, but a role for coronin 1 in natural killer (NK) cell homeostasis and function remains unclear. Here, we have analyzed the number and functionality of NK cells in the presence and absence of coronin 1. In coronin 1-deficient mice, absolute NK cell numbers and phenotype were comparable to wild type mice in blood, spleen and liver. Following in vitro stimulation of the activating NK cell receptors NK1.1, NKp46, Ly49D and NKG2D, coronin 1-deficient NK cells were functional with respect to interferon-γ production, degranulation and intracellular Ca(2+) mobilization. Also, both wild type as well as coronin 1-deficient NK cells showed comparable cytotoxic activity. Furthermore, activation and functionality of NK cells following Vesicular Stomatitis Virus (VSV) infection was similar between wild type and coronin 1-deficient mice. Taken together these data suggest that coronin 1 is dispensable for mouse NK cell homeostasis and function.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Urban & Fischer
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Aug 2018 13:18
Deposited On:26 Oct 2017 12:29

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