Pasakarnis, Laurynas and Frei, Erich and Caussinus, Emmanuel and Affolter, Markus and Brunner, Damian. (2016) Amnioserosa cell constriction but not epidermal actin cable tension autonomously drives dorsal closure. Nature Cell Biology , 18 (11). pp. 1161-1172.
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Abstract
Tissue morphogenesis requires coordination of multiple force-producing components. During dorsal closure in fly embryogenesis, an epidermis opening closes. A tensioned epidermal actin/MyosinII cable, which surrounds the opening, produces a force that is thought to combine with another MyosinII force mediating apical constriction of the amnioserosa cells that fill the opening. A model proposing that each force could autonomously drive dorsal closure was recently challenged by a model in which the two forces combine in a ratchet mechanism. Acute force elimination via selective MyosinII depletion in one or the other tissue shows that the amnioserosa tissue autonomously drives dorsal closure while the actin/MyosinII cable cannot. These findings exclude both previous models, although a contribution of the ratchet mechanism at dorsal closure onset remains likely. This shifts the current view of dorsal closure being a combinatorial force-component system to a single tissue-driven closure event.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter) |
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UniBasel Contributors: | Affolter, Markus |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Nature Publishing Group |
ISSN: | 1465-7392 |
e-ISSN: | 1476-4679 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 08 Feb 2022 18:11 |
Deposited On: | 25 Oct 2017 15:07 |
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