Liu, Xiaolong and BoseDasgupta, Somdeb and Jayachandran, Rajesh and Studer, Vera and Rühl, Sebastian and Stiess, Michael and Pieters, Jean. (2016) Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity. FEBS Letters, 590 (2). pp. 279-287.
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Official URL: http://edoc.unibas.ch/44401/
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Abstract
Coronins constitute a family of conserved proteins expressed in all eukaryotes that have been implicated in the regulation of a wide variety of cellular activities. Recent work showed an essential role for coronin 1 in the modulation of the cAMP/PKA pathway in neurons through the interaction of coronin 1 with the G protein subtype Gαs in a stimulus-dependent manner, but the molecular mechanism regulating coronin 1-Gαs interaction remains unclear. We here show that phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-Gαs association and the modulation of cAMP production. Together these results show an essential role for CDK5 activity in promoting the coronin 1-dependent cAMP/PKA pathway.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters) |
|---|---|
| UniBasel Contributors: | Pieters, Jean |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley-Blackwell |
| ISSN: | 0014-5793 |
| e-ISSN: | 1873-3468 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 26 Oct 2017 12:24 |
| Deposited On: | 26 Oct 2017 12:24 |
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