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Comparative study of activities of a diverse set of antimycobacterial agents against Mycobacterium tuberculosis and Mycobacterium ulcerans

Scherr, Nicole and Pluschke, Gerd and Panda, Manoranjan. (2016) Comparative study of activities of a diverse set of antimycobacterial agents against Mycobacterium tuberculosis and Mycobacterium ulcerans. Antimicrobial agents and chemotherapy, 60 (5). pp. 3132-3137.

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Official URL: http://edoc.unibas.ch/43651/

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Abstract

A library of compounds covering a broad chemical space was selected from a tuberculosis drug development program and was screened in a whole-cell assay against Mycobacterium ulcerans, the causative agent of the necrotizing skin disease Buruli ulcer. While a number of potent antitubercular agents were only weakly active or inactive against M. ulcerans, five compounds showed high activity (90% inhibitory concentration [IC90], ≤1 μM), making screening of focused antitubercular libraries a good starting point for lead generation against M. ulcerans.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Scherr, Nicole and Pluschke, Gerd
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society for Microbiology
ISSN:0066-4804
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 Aug 2016 13:56
Deposited On:31 Aug 2016 13:56

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