Scherr, Nicole and Pluschke, Gerd and Panda, Manoranjan. (2016) Comparative study of activities of a diverse set of antimycobacterial agents against Mycobacterium tuberculosis and Mycobacterium ulcerans. Antimicrobial agents and chemotherapy, 60 (5). pp. 3132-3137.
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Abstract
A library of compounds covering a broad chemical space was selected from a tuberculosis drug development program and was screened in a whole-cell assay against Mycobacterium ulcerans, the causative agent of the necrotizing skin disease Buruli ulcer. While a number of potent antitubercular agents were only weakly active or inactive against M. ulcerans, five compounds showed high activity (90% inhibitory concentration [IC90], ≤1 μM), making screening of focused antitubercular libraries a good starting point for lead generation against M. ulcerans.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Molecular Immunology (Pluschke) |
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| UniBasel Contributors: | Scherr, Nicole and Pluschke, Gerd |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 31 Aug 2016 13:56 |
| Deposited On: | 31 Aug 2016 13:56 |
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