Anti-staphylococcal prenylated acylphoroglucinol and xanthones from Kielmeyera variabilis (Clusiaceae)

Coqueiro, Aline and Choi, Young H. and Verpoorte, Robert and Sankar Gupta, Karthick B. S. and De Mieri, Maria and Hamburger, Matthias and Marx Young, Maria C. and Stapleton, Paul and Gibbons, Simon and da Silva Bolzani, Vanderlan. (2016) Anti-staphylococcal prenylated acylphoroglucinol and xanthones from Kielmeyera variabilis (Clusiaceae). Journal of natural products, 79 (3). pp. 470-476.

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Official URL: http://edoc.unibas.ch/43377/

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Bioactivity-guided fractionation of the EtOH extract of the branches of Kielmeyera variabilis led to the isolation of a new acylphoroglucinol (1), which was active against all the MRSA strains tested herein, with pronounced activity against strain EMRSA-16. Compound 1 displayed an MIC of 0.5 mg/L as compared with an MIC of 128 mg/L for the control antibiotic norfloxacin. The structure of the new compound was elucidated by 1D and 2D NMR spectroscopic analysis and mass spectrometry, and experimental and calculated ECD were used to determine the absolute configurations. The compounds β-sitosterol (2), stigmasterol (3), ergost-5-en-3-ol (4), and osajaxanthone (5) also occurred in the n-hexane fraction. The EtOAc fraction contained nine known xanthones: 3,6-dihydroxy-1,4,8-trimethoxyxanthone (6), 3,5-dihydroxy-4-methoxyxanthone (7), 3,4-dihydroxy-6,8-dimethoxyxanthone (8), 3,4-dihydroxy-2-methoxyxanthone (9), 5-hydroxy-1,3-dimethoxyxanthone (10), 4-hydroxy-2,3-dimethoxyxanthone (11), kielcorin (12), 3-hydroxy-2-methoxyxanthone (13), and 2-hydroxy-1-methoxyxanthone (14), which showed moderate to low activity against the tested MRSA strains.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Hamburger, Matthias and de Mieri, Maria
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society of Pharmacognosy
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:13 Dec 2016 08:29
Deposited On:13 Dec 2016 08:29

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