Swierczynska, Marta M. and Hall, Michael N.. (2016) eIF4A moonlights as an off switch for TORC1. The EMBO Journal, 35 (10). pp. 1013-1014.
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Official URL: http://edoc.unibas.ch/42501/
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Abstract
TORC1 is actively inhibited upon amino acid withdrawal. Tsokanos et al (2016) shed light on the underlying molecular mechanism. They demonstrate that upon removal of exogenous amino acids, eIF4A inhibits TORC1 via TSC2. Thus, whereas it is well known that TORC1 regulates the translation machinery, we now know the inverse is also true.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall) |
|---|---|
| UniBasel Contributors: | Hall, Michael N. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Nature Publishing Group |
| ISSN: | 0261-4189 |
| e-ISSN: | 1460-2075 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 09 Nov 2017 08:21 |
| Deposited On: | 22 Nov 2016 10:27 |
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