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Elemental constituents of particulate matter and newborn's size in eight European cohorts

Pedersen, Marie and Gehring, Ulrike and Beelen, Rob and Wang, Meng and Giorgis-Allemand, Lise and Andersen, Anne-Marie Nybo and Basagaña, Xavier and Bernard, Claire and Cirach, Marta and Forastiere, Francesco and de Hoogh, Kees and Gražulevičvienė, Regina and Gruzieva, Olena and Hoek, Gerard and Jedynska, Aleksandra and Klümper, Claudia and Kooter, Ingeborg M. and Krämer, Ursula and Kukkonen, Jaakko and Porta, Daniela and Postma, Dirkje S. and Raaschou-Nielsen, Ole and van Rossem, Lenie and Sunyer, Jordi and Sørensen, Mette and Tsai, Ming-Yi and Vrijkotte, Tanja G. M. and Wilhelm, Michael and Nieuwenhuijsen, Mark J. and Pershagen, Göran and Brunekreef, Bert and Kogevinas, Manolis and Slama, Rémy. (2016) Elemental constituents of particulate matter and newborn's size in eight European cohorts. Environmental Health Perspectives, 124 (1). pp. 141-150.

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Abstract

The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn's size have been little examined.; We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW; weight < 2,500 g among births after 37 weeks of gestation), mean birth weight, and head circumference, relying on standardized fine-scale exposure assessment and with extensive control for potential confounders.; We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM ≤ 2.5 and ≤ 10 μm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) were calculated using random-effects regression on pooled data.; A 200-ng/m3 increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio = 1.36; 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10.; Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.; Pedersen M, Gehring U, Beelen R, Wang M, Giorgis-Allemand L, Andersen AM, Basagaña X, Bernard C, Cirach M, Forastiere F, de Hoogh K, Gražulevičienė R, Gruzieva O, Hoek G, Jedynska A, Klümper C, Kooter IM, Krämer U, Kukkonen J, Porta D, Postma DS, Raaschou-Nielsen O, van Rossem L, Sunyer J, Sørensen M, Tsai MY, Vrijkotte TG, Wilhelm M, Nieuwenhuijsen MJ, Pershagen G, Brunekreef B, Kogevinas M, Slama R. 2016. Elemental constituents of particulate matter and newborn's size in eight European cohorts. Environ Health Perspect 124:141-150; http://dx.doi.org/10.1289/ehp.1409546.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Exposure Science (Tsai)
UniBasel Contributors:de Hoogh, Kees and Tsai, Ming
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Institute of Environmental Health Sciences
ISSN:0091-6765
e-ISSN:1552-9924
Note:Publication type according to Uni Basel Research Database: Journal article -- Reproduced with permission from Environmental Health Perspectives
Language:English
Identification Number:
Last Modified:31 Aug 2017 08:31
Deposited On:21 Apr 2016 09:09

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