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Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus

Nurjadi, D. and Schäfer, J. and Friedrich-Jänicke, B. and Mueller, A. and Neumayr, A. and Calvo-Cano, A. and Goorhuis, A. and Molhoek, N. and Lagler, H. and Kantele, A. and Van Genderen, P. J. J. and Gascon, J. and Grobusch, M. P. and Caumes, E. and Hatz, C. and Fleck, R. and Mockenhaupt, F. P. and Zanger, P.. (2015) Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus. Clinical microbiology and infection, 21 (12). 1095.e5-1095.e9.

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Official URL: http://edoc.unibas.ch/41552/

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Abstract

To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Medicine > Medical Services (Neumayr)
UniBasel Contributors:Hatz, Christoph and Neumayr, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Blackwell
ISSN:1198-743X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Jun 2016 11:02
Deposited On:13 Apr 2016 13:16

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