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A multinational case-control study on childhood brain tumours, anthropogenic factors, birth characteristics and prenatal exposures : a validation of interview data

Vienneau, Danielle and Infanger, Denis and Feychting, Maria and Schüz, Joachim and Schmidt, Lisbeth Samsø and Poulsen, Aslak Harbo and Tettamanti, Giorgio and Klæboe, Lars and Kuehni, Claudia E. and Tynes, Tore and Von der Weid, Nicolas and Lannering, Birgitta and Röösli, Martin. (2015) A multinational case-control study on childhood brain tumours, anthropogenic factors, birth characteristics and prenatal exposures : a validation of interview data. Cancer epidemiology, 40. pp. 52-59.

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Abstract

Little is known about the aetiology of childhood brain tumours. We investigated anthropometric factors (birth weight, length, maternal age), birth characteristics (e.g. vacuum extraction, preterm delivery, birth order) and exposures during pregnancy (e.g. maternal: smoking, working, dietary supplement intake) in relation to risk of brain tumour diagnosis among 7-19 year olds. The multinational case-control study in Denmark, Sweden, Norway and Switzerland (CEFALO) included interviews with 352 (participation rate=83.2%) eligible cases and 646 (71.1%) population-based controls. Interview data were complemented with data from birth registries and validated by assessing agreement (Cohen's Kappa). We used conditional logistic regression models matched on age, sex and geographical region (adjusted for maternal age and parental education) to explore associations between birth factors and childhood brain tumour risk. Agreement between interview and birth registry data ranged from moderate (Kappa=0.54; worked during pregnancy) to almost perfect (Kappa=0.98; birth weight). Neither anthropogenic factors nor birth characteristics were associated with childhood brain tumour risk. Maternal vitamin intake during pregnancy was indicative of a protective effect (OR 0.75, 95%-CI: 0.56-1.01). No association was seen for maternal smoking during pregnancy or working during pregnancy. We found little evidence that the considered birth factors were related to brain tumour risk among children and adolescents.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Vienneau, Danielle and Röösli, Martin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1877-7821
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:17 Dec 2018 15:08
Deposited On:13 Apr 2016 12:12

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