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Trapping, entrainment and synchronization of semiflexible polymers in narrow, asymmetric confinements

Swank, Zoe and Deshpande, Siddharth and Pfohl, Thomas. (2016) Trapping, entrainment and synchronization of semiflexible polymers in narrow, asymmetric confinements. Soft matter, 12 (1). pp. 87-92.

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Abstract

The physical properties of polymeric actin facilitate many mechanical processes within the cell, including cellular deformation and locomotion, whereby the polymers can be confined to a range of different geometries. As actin polymers often form entangled solutions in the cell, we have investigated the effect of confinement on the evolution of entangled semiflexible polymer solutions. Using a microfluidic platform, we examined the physical dynamics of actin polymers confined within narrow (2-4 μm) rectangular channels. Focusing on the entanglement process of two actin polymers, we found that their prolonged entrainment leads to synchronized horizontal undulations and decreased translational diffusion. In the absence of cross-linking molecules or proteins, the long-range entrainment interactions are predominantly controlled by the geometric boundaries. We directly measure the deflection length Λ for an individual polymer, either solitarily confined within a channel or confined in the presence of a second filament, enabling the determination of the change in free energy associated with polymer entanglement. Our results indicate that geometrical confinement can serve as a solitary variable influencing the physical dynamics of entangled semiflexible polymers.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Biophysikalische Chemie (Pfohl)
UniBasel Contributors:Pfohl, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:1744-6848
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:02 Jul 2019 08:11
Deposited On:18 May 2016 11:43

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