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Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study

Hansen, Sofie and Probst-Hensch, Nicole and Keidel, Dirk and Dratva, Julia and Bettschart, Robert and Pons, Marco and Burdet, Luc and Bridevaux, Pierre-Olivier and Schikowski, Tamara and Schindler, Christian and Rochat, Thierry and Zemp, Elisabeth. (2015) Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study. The European respiratory journal, 46 (4). pp. 1011-1020.

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Official URL: http://edoc.unibas.ch/39829/

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Abstract

A higher incidence of asthma is reported in women compared with men, but evidence in later adulthood is limited. We aimed to determine the 20-year cumulative incidence of adult asthma in Switzerland and its relation to sex, taking into account age and allergic sensitisation.We assessed incidence of self-report of doctor-diagnosed asthma between 1991/1992 and 2010/2011 in 5128 subjects without asthma, aged 18-60 years at baseline. The age-related probability of asthma onset was analysed by logistic regression adjusting for potential confounders and stratified by sex and allergic sensitisation at baseline.Over 20 years, 128 (5.1%) men and 198 (7.5%) women newly reported doctor-diagnosed asthma. The adjusted odds ratio for female sex was 1.99 (95% CI 1.54-2.57) overall, 3.21 (95% CI 2.12-4.85) among nonsensitised subjects, and 1.43 (95% CI 1.02-2.02) in sensitised subjects. The probability of asthma onset decreased with increasing baseline age in women but not in men. The higher probability of new asthma in sensitised compared with nonsensitised men was unrelated to age, whereas in women it decreased with age.Asthma incidence was higher in women than in men but decreased with increasing age. The female predominance was considerably stronger in nonsensitised adults compared with those with allergic sensitisation.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Hansen, Sofie and Probst Hensch, Nicole and Keidel, Dirk and Dratva, Julia and Schikowski, Tamara and Schindler, Christian and Zemp Stutz, Elisabeth
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 May 2018 09:30
Deposited On:27 Jan 2016 09:01

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