Stimuli-Triggered Activity of Nanoreactors by Biomimetic Engineering Polymer Membranes

Einfalt, Tomaz and Goers, Roland and Dinu, Ionel Adrian and Najer, Adrian and Spulber, Mariana and Onaca-Fischer, Ozana and Palivan, Cornelia G. . (2015) Stimuli-Triggered Activity of Nanoreactors by Biomimetic Engineering Polymer Membranes. Nano Letters, 15 (11). pp. 7596-7603.

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Official URL: http://edoc.unibas.ch/39772/

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The development of advanced stimuli-responsive systems for medicine, catalysis, or technology requires compartmentalized reaction spaces with triggered activity. Only very few stimuli-responsive systems preserve the compartment architecture, and none allows a triggered activity in situ. We present here a biomimetic strategy to molecular transmembrane transport by engineering synthetic membranes equipped with channel proteins so that they are stimuli-responsive. Nanoreactors with triggered activity were designed by simultaneously encapsulating an enzyme inside polymer compartments, and inserting protein “gates” in the membrane. The outer membrane protein F (OmpF) porin was chemically modified with a pH-responsive molecular cap to serve as “gate” producing pH-driven molecular flow through the membrane and control the in situ enzymatic activity. This strategy provides complex reaction spaces necessary in “smart” medicine and for biomimetic engineering of artificial cells.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G and Einfalt, Tomaz and Fischer, Ozana Simina and Goers, Roland
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Apr 2018 12:00
Deposited On:14 Jun 2017 07:03

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