edoc

Body composition and adiponectin serum concentrations in adult patients with cystic fibrosis

Moriconi, Natascha and Kraenzlin, Marius and Muller, Beat and Keller, Ulrich and Nusbaumer, Charly P. G. and Stohr, Susie and Tamm, Michael and Puder, Jardena J.. (2006) Body composition and adiponectin serum concentrations in adult patients with cystic fibrosis. Journal of Clinical Endocrinology and Metabolism, Vol. 91, H. 4. pp. 1586-1590.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6419963

Downloads: Statistics Overview

Abstract

CONTEXT: Cystic fibrosis (CF) is a disease characterized by weight loss and chronic low-grade inflammation. OBJECTIVE: The objective of the study was to assess changes in body composition and the serum concentrations of adiponectin, a marker of negative energy balance and insulin sensitivity, in adult patients with CF. DESIGN: This was a cross-sectional study. SETTING: The study was conducted at an outpatient clinic of the University Hospital of Basel, Switzerland. PARTICIPANTS: Twenty-four stable adult CF patients and 24 healthy controls, matched for body mass index, age, sex, and hormonal therapy in women participated in the study. MAIN OUTCOME MEASURES: Changes in body composition (assessed by dual x-ray absorptiometry) and serum adiponectin levels were measured. RESULTS: Body mass index, percent fat mass (in percentage of body weight), and percent lean body mass were similar in patients and controls, whereas central fat accumulation was increased [trunk to extremity fat ratio 1.2 (0.99-1.51) vs. 0.99 (0.81-1.25), P = 0.01] in patients with CF, compared with controls. Decreased lean mass and increased highly sensitive C-reactive protein levels were independently associated with worse lung function in CF patients. Despite similar insulin resistance (homeostasis model assessment) and similar SHBG serum concentrations, the serum concentrations of adiponectin were higher in CF patients, compared with controls, independent of other confounders (P = 0.01). CONCLUSIONS: Central fat accumulation is increased in patients with CF. It is postulated that the energy deficit-induced increase in serum adiponectin could explain the preservation of insulin sensitivity in these patients despite the increase in central fat and in highly sensitive C-reactive protein serum concentrations and could prevent a further deterioration of protein catabolism.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Metabolism (Keller/Müller)
UniBasel Contributors:Keller, Ulrich O. and Müller, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0021-972X
e-ISSN:1945-7197
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Nov 2017 11:23
Deposited On:02 Oct 2015 10:00

Repository Staff Only: item control page