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In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue

Linscheid, Philippe and Seboek, Dalma and Nylen, Eric S. and Langer, Igor and Schlatter, Mirjam and Becker, Kenneth L. and Keller, Ulrich and Muller, Beat. (2003) In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue. Endocrinology, Vol. 144, H. 12. pp. 5578-5584.

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Official URL: http://edoc.unibas.ch/dok/A6419886

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Abstract

Circulating levels of calcitonin precursors (CTpr), including procalcitonin (ProCT), increase up to several thousand-fold in human sepsis, and immunoneutralization improves survival in two animal models of this disease. Herein, we analyzed inflammation-mediated calcitonin I gene (CALC I) expression in human adipocyte primary cultures and in adipose tissue samples from infected and noninfected patients with different levels of serum ProCT. In ex vivo differentiated adipocytes, the expression of CT mRNA increased 24-fold (P textless 0.05) after the administration of Escherichia coli endotoxin (lipopolysaccharide) and
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Klinische Endokrinologie (Keller)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Metabolism (Keller/Müller)
UniBasel Contributors:Keller, Ulrich O. and Müller, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:0013-7227
e-ISSN:1945-7170
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Nov 2017 07:36
Deposited On:02 Oct 2015 10:00

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