Molecular anatomy of a trafficking organelle

Takamori, Shigeo and Holt, Matthew and Stenius, Katinka and Lemke, Edward A. and Gronborg, Mads and Riedel, Dietmar and Urlaub, Henning and Schenck, Stephan and Bruegger, Britta and Ringler, Philippe and Müller, Shirley A. and Rammner, Burkhard and Graeter, Frauke and Hub, Jochen S. and De Groot, Bert L. and Mieskes, Gottfried and Moriyama, Yoshinori and Klingauf, Juergen and Grubmueller, Helmut and Heuser, John and Wieland, Felix and Jahn, Reinhard. (2006) Molecular anatomy of a trafficking organelle. Cell, Vol. 127, H. 4. pp. 831-846.

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Official URL: http://edoc.unibas.ch/dok/A5262474

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Membrane traffic in eukaryotic cells involves transport of vesicles that bud from a donor compartment and fuse with an acceptor compartment. Common principles of budding and fusion have emerged, and many of the proteins involved in these events are now known. However, a detailed picture of an entire trafficking organelle is not yet available. Using synaptic vesicles as a model, we have now detd. the protein and lipid compn.; measured vesicle size, d., and mass; calcd. the av. protein and lipid mass per vesicle; and detd. the copy no. of more than a dozen major constituents. A model has been constructed that integrates all quant. data and includes structural models of abundant proteins. Synaptic vesicles are dominated by proteins, possess a surprising diversity of trafficking proteins, and, with the exception of the V-ATPase that is present in only one to two copies, contain numerous copies of proteins essential for membrane traffic and neuro-transmitter uptake. [on SciFinder (R)]
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
UniBasel Contributors:Müller, Shirley and Ringler, Philippe
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:24

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