Graf, Fabrice E. and Baker, Nicola and Munday, Jane C. and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2015) Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International journal for parasitology. Drugs and drug resistance, Vol. 5, H. 2. pp. 65-68.
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Official URL: http://edoc.unibas.ch/dok/A6390996
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Abstract
Aquaglyceroporin-2 is a known determinant of melarsoprol-pentamidine cross-resistance in Trypanosoma brucei brucei laboratory strains. Recently, chimerization at the AQP2-AQP3 tandem locus was described from melarsoprol-pentamidine cross-resistant Trypanosoma brucei gambiense isolates from sleeping sickness patients in the Democratic Republic of the Congo. Here, we demonstrate that reintroduction of wild-type AQP2 into one of these isolates fully restores drug susceptibility while expression of the chimeric AQP2/3 gene in aqp2-aqp3 null T. b. brucei does not. This proves that AQP2-AQP3 chimerization is the cause of melarsoprol-pentamidine cross-resistance in the T. b. gambiense isolates.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Mäser, Pascal |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier] |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 03 Jul 2015 08:53 |
| Deposited On: | 03 Jul 2015 08:53 |
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