Natural-cause mortality and long-term exposure to particle components : an analysis of 19 European cohorts within the multi-center ESCAPE project

Beelen, Rob and Hoek, Gerard and Raaschou-Nielsen, Ole and Stafoggia, Massimo and Andersen, Zorana Jovanovic and Weinmayr, Gudrun and Hoffmann, Barbara and Wolf, Kathrin and Samoli, Evangelia and Fischer, Paul H. and Nieuwenhuijsen, Mark J. and Xun, Wei W. and Katsouyanni, Klea and Dimakopoulou, Konstantina and Marcon, Alessandro and Vartiainen, Erkki and Lanki, Timo and Yli-Tuomi, Tarja and Oftedal, Bente and Schwarze, Per E. and Nafstad, Per and De Faire, Ulf and Pedersen, Nancy L. and Östenson, Claes-Göran and Fratiglioni, Laura and Penell, Johanna and Korek, Michal and Pershagen, Göran and Eriksen, Kirsten Thorup and Overvad, Kim and Sørensen, Mette and Eeftens, Marloes and Peeters, Petra H. and Meliefste, Kees and Wang, Meng and Bueno-de-Mesquita, H. Bas and Sugiri, Dorothea and Krämer, Ursula and Heinrich, Joachim and de Hoogh, Kees and Key, Timothy and Peters, Annette and Hampel, Regina and Concin, Hans and Nagel, Gabriele and Jaensch, Andrea and Ineichen, Alex and Tsai, Ming-Yi and Schaffner, Emmanuel and Probst-Hensch, Nicole M. and Schindler, Christian and Ragettli, Martina S. and Vilier, Alice and Clavel-Chapelon, Françoise and Declercq, Christophe and Ricceri, Fulvio and Sacerdote, Carlotta and Galassi, Claudia and Migliore, Enrica and Ranzi, Andrea and Cesaroni, Giulia and Badaloni, Chiara and Forastiere, Francesco and Katsoulis, Michail and Trichopoulou, Antonia and Keuken, Menno and Jedynska, Aleksandra and Kooter, Ingeborg M. and Kukkonen, Jaakko and Sokhi, Ranjeet S. and Vineis, Paolo and Brunekreef, Bert. (2015) Natural-cause mortality and long-term exposure to particle components : an analysis of 19 European cohorts within the multi-center ESCAPE project. Environmental Health Perspectives, 123 (6). pp. 525-533.

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Abstract

Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality.; Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter.; Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori-selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis.; The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced.; Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Exposome Science (Probst-Hensch) 03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Exposome Science (Probst-Hensch) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics Frequentist Modelling (Kwiatkowski)
UniBasel Contributors:	Eeftens, Marloes and Eeftens, Marloes and de Hoogh, Kees and Ineichen, Alex and Tsai, Ming and Schaffner, Emmanuel and Probst Hensch, Nicole and Schindler, Christian and Ragettli, Martina
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	National Institute of Environmental Health Sciences
ISSN:	0091-6765
e-ISSN:	1552-9924
Note:	Publication type according to Uni Basel Research Database: Journal article -- Reproduced with permission from Environmental Health Perspectives
Language:	English
Identification Number:	doi: 10.1289/ehp.1408095 pmid: 25712504
edoc DOI:	10.5451/unibas-ep37606
Last Modified:	31 Aug 2017 08:36
Deposited On:	03 Jul 2015 08:53

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