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Nuclear protein transport is functionally conserved between yeast and higher eukaryotes

Wagner, P. and Hall, M. N.. (1993) Nuclear protein transport is functionally conserved between yeast and higher eukaryotes. FEBS Letters, 321 (2-3). pp. 261-266.

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Official URL: http://edoc.unibas.ch/dok/A5262075

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Abstract

The ability of a yeast nuclear protein to be transported into the nucleus of a higher eukaryotic cell was investigated. Mcm1, a transcriptional activator protein from Saccharomyces cerevisiae, was microinjected into the cytoplasm of Xenopus laevis frog oocytes. Mcm1 was imported into the oocyte nucleus indicating that the machinery for nuclear transport is conserved from yeast to higher eukaryotes. Furthermore, by comparing the nuclear import of free proteins and protein-gold complexes, we found that protein-gold complex formation appears to partially and specifically inactivate the nuclear transport activity of Mcm1 and that nucleoplasmin is an exceptionally good nuclear import substrate.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0014-5793
e-ISSN:1873-3468
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Nov 2017 13:58
Deposited On:22 Mar 2012 13:23

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