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Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense : review

Steinmann, Peter and Stone, Christopher M. and Sutherland, C. Simone and Tanner, Marcel and Tediosi, Fabrizio. (2015) Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense : review. Tropical medicine and international health, 20 (6). pp. 707-718.

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Official URL: http://edoc.unibas.ch/dok/A6381880

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Abstract

To review current and emerging tools for Gambiense HAT control and elimination, and propose strategies that integrate these tools with epidemiological evidence.; We reviewed the scientific literature to identify contemporary and emerging tools and strategies for controlling and eliminating Gambiense HAT. Through an iterative process involving key stakeholders, we then developed comprehensive scenarios leading to elimination, considering both established and new tools for diagnosis, case treatment and vector control.; Core components of all scenarios include detecting and treating cases with established or emerging techniques. Relatively more intensive scenarios incorporate vector control. New tools considered include tiny targets for tsetse fly control, use of rapid diagnostic tests and oral treatment with fexinidazole or oxaboroles. Scenarios consider the time when critical new tools are expected to become ready for deployment by national control programmes. Based on a review of the latest epidemiological data, we estimate the various interventions to cover 1380 600 km(2) and 56 986 000 people.; A number of new tools will fill critical gaps in the current armamentarium for diagnosing and treating Gambiense HAT. Deploying these tools in endemic areas will facilitate the comprehensive and sustainable control of the disease considerably and contribute to the ultimate goal of elimination.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Steinmann, Peter and Tanner, Marcel and Tediosi, Fabrizio
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell Science
ISSN:1360-2276
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Sep 2018 12:40
Deposited On:03 Jul 2015 08:53

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