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Mefloquine at the crossroads? : Implications for malaria prophylaxis in Europa

Schlagenhauf, P. and Hatz, C. and Behrens, R. and Visser, L. and Funk, M. and Holzer, B. and Beck, B. and Bourquin, C. and Etter, H. and Furrer, H. and Genton, B. and Landry, P. and Chappuis, F. and Loutan, L. and Stossel, U. and Jeschko, E. and Rossano, A. and Nothdurft, H. D.. (2015) Mefloquine at the crossroads? : Implications for malaria prophylaxis in Europa. Travel medicine and infectious disease, Vol. 13, H. 2. pp. 192-196.

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Official URL: http://edoc.unibas.ch/dok/A6373547

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Abstract

Since its introduction to the market in 1985, mefloquine has been used for malaria chemoprophylaxis by more than 35 million travellers. In Europe, in 2014, the European Medicines Agency (EMA) issued recommendations on strengthened warnings, prescribing checklists and updates to the product information of mefloquine. Some malaria prevention advisors question the scientific basis for the restrictions and suggest that this cost-effective, anti-malarial drug will be displaced as a first-line anti-malaria medication with the result that vulnerable groups such as VFR and long-term travellers, pregnant travellers and young children are left without a suitable alternative chemoprophylaxis. This commentary looks at the current position of mefloquine prescribing and the rationale of the new EMA recommendations and restrictions. It also describes the new recommendations for malaria prophylaxis that have been adapted by Switzerland, Germany, Austria and Italy where chemoprophylaxis use is restricted to high-risk malaria-endemic areas.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Clinical Epidemiology (Genton)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Medicine > Medical Services (Neumayr)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Hatz, Christoph and Beck, Bernhard and Genton, Blaise
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1477-8939
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:03 Jul 2015 08:53
Deposited On:03 Jul 2015 08:53

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