Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood : a European mother-child study (NewGeneris)

Pedersen, Marie and Mendez, Michelle A. and Schoket, Bernadette and Godschalk, Roger W. and Espinosa, Ana and Landström, Anette and Villanueva, Cristina M. and Merlo, Domenico F. and Fthenou, Eleni and Gracia-Lavedan, Esther and van Schooten, Frederik-J. and Hoek, Gerard and Brunborg, Gunnar and Meltzer, Helle M. and Alexander, Jan and Nielsen, Jeanette K. and Sunyer, Jordi and Wright, John and Kovács, Katalin and de Hoogh, Kees and Gutzkow, Kristine B. and Hardie, Laura J. and Chatzi, Leda and Knudsen, Lisbeth E. and Anna, Lívia and Ketzel, Matthias and Haugen, Margaretha and Botsivali, Maria and Nieuwenhuijsen, Mark J. and Cirach, Marta and Toledano, Mireille B. and Smith, Rachel B. and Fleming, Sarah and Agramunt, Silvia and Kyrtopoulos, Soterios A. and Lukács, Viktória and Kleinjans, Jos C. and Segerbäck, Dan and Kogevinas, Manolis. (2015) Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood : a European mother-child study (NewGeneris). Environmental Health Perspectives, 123 (4). pp. 374-380.

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Official URL: http://edoc.unibas.ch/dok/A6373537

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Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk.; We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates.; Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population.; Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p > 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.; These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.;
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health Systems Research > Physical Hazards and Health (Röösli)
UniBasel Contributors:de Hoogh, Kees
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Institute of Environmental Health Sciences
Note:Publication type according to Uni Basel Research Database: Journal article -- Reproduced with permission from Environmental Health Perspectives
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Last Modified:31 Aug 2017 08:44
Deposited On:05 Jun 2015 08:52

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