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Recombination between variants from genital tract and plasma : evolution of multidrug-resistant HIV type 1

Kemal, K. S. and Ramirez, C. M. and Burger, H. and Foley, B. and Mayers, D. and Klimkait, T. and Hamy, F. and Anastos, K. and Petrovic, K. and Minin, V. N. and Suchard, M. A. and Weiser, B.. (2012) Recombination between variants from genital tract and plasma : evolution of multidrug-resistant HIV type 1. Aids research and human retroviruses, Vol. 28, H. 12. pp. 1766-1774.

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Official URL: http://edoc.unibas.ch/dok/A6338397

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Abstract

Multidrug-resistant (MDR) HIV-1 presents a challenge to the efficacy of antiretroviral therapy (ART). To examine mechanisms leading to MDR variants in infected individuals, we studied recombination between single viral genomes from the genital tract and plasma of a woman initiating ART. We determined HIV-1 RNA sequences and drug resistance profiles of 159 unique viral variants obtained before ART and semiannually for 4 years thereafter. Soon after initiating zidovudine, lamivudine, and nevirapine, resistant variants and intrapatient HIV-1 recombinants were detected in both compartments; the recombinants had inherited genetic material from both genital and plasma-derived viruses. Twenty-three unique recombinants were documented during 4 years of therapy, comprising similar to 22% of variants. Most recombinant genomes displayed similar breakpoints and clustered phylogenetically, suggesting evolution from common ancestors. Longitudinal analysis demonstrated that MDR recombinants were common and persistent, demonstrating that recombination, in addition to point mutation, can contribute to the evolution of MDR HIV-1 in viremic individuals.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Molecular Virology (Klimkait)
UniBasel Contributors:Klimkait, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Mary Ann Liebert
ISSN:0889-2229
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 May 2015 08:45
Deposited On:08 May 2015 08:45

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