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Neural progenitor cells regulate microglia functions and activity

Mosher, K. I. and Andres, R. H. and Fukuhara, T. and Bieri, G. and Hasegawa-Moriyama, M. and He, Y. and Guzman, R. and Wyss-Coray, T.. (2012) Neural progenitor cells regulate microglia functions and activity. Nature neuroscience, Vol. 15, H. 11. pp. 1485-1487.

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Official URL: http://edoc.unibas.ch/dok/A6338580

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Abstract

We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Brain Ischemia and Regeneration (Guzman)
UniBasel Contributors:Guzman, Raphael
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature America
ISSN:1097-6256
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 May 2015 08:45
Deposited On:08 May 2015 08:45

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