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Meniscectomy leads to early changes in the mineralization distribution of subchondral bone plate

Anetzberger, H. and Mayer, A. and Glaser, C. and Lorenz, S. and Birkenmaier, C. and Muller-Gerbl, M.. (2012) Meniscectomy leads to early changes in the mineralization distribution of subchondral bone plate. Knee surgery, sports traumatology, arthroscopy, Vol. 22, H. 1. pp. 112-119.

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Official URL: http://edoc.unibas.ch/dok/A6338244

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Abstract

PURPOSE: It is generally recognized that the subchondral bone plate (SBP) is involved in development of osteoarthritis (OA). However, the pathophysiological significance is not yet clear. The goal of this study is to investigate the extent of the changes that occur in SBP of the tibial plateau in the early stages of experimental OA. METHODS: Forty-three female rabbits were assigned to 5 experimental (n = 8 each group) and one sham group (n = 3). OA was induced by medial meniscectomy in the right knee, the left knee served as control. 2, 4, 8, 12, and 24 weeks after meniscectomy, cartilage damage was evaluated, and bone mineral density (BMD) and mineralization distribution of the SBP was measured by computed tomography osteoabsorptiometry (CT-OAM). RESULTS: Cartilage damage started 2 weeks after meniscectomy with surface roughening. Cartilage defects increased over time. 24 weeks postoperatively, subchondral bone was exposed. As early as 2 weeks after meniscectomy, BMD in the medial tibial plateau decreased significantly. BMD increased again and reached the values of the non-operated knee 12 weeks postoperatively. In addition, already 4 weeks after meniscectomy a significant shift of the densitiy maximum on the medial tibial plateau, which is normally centrally located toward the margin was observed. CONCLUSIONS: In conclusion, the results of this study contribute to the concept of early involvement of the SBP in the development of OA. The hypothesis that changes in the SBP occur simultaneously to cartilage damage was confirmed.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Musculosceletal Research (Müller-Gerbl)
UniBasel Contributors:Müller-Gerbl, Magdalena
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0942-2056
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:14
Deposited On:10 Apr 2015 09:14

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