Natalizumab treatment for multiple sclerosis : updated recommendations for patient selection and monitoring

Kappos, L. and Bates, D. and Edan, G. and Eraksoy, M. and Garcia-Merino, A. and Grigoriadis, N. and Hartung, H. P. and Havrdova, E. and Hillert, J. and Hohlfeld, R. and Kremenchutzky, M. and Lyon-Caen, O. and Miller, A. and Pozzilli, C. and Ravnborg, M. and Saida, T. and Sindic, C. and Vass, K. and Clifford, D. B. and Hauser, S. and Major, E. O. and O'Connor, P. W. and Weiner, H. L. and Clanet, M. and Gold, R. and Hirsch, H. H. and Radu, E. W. and Sorensen, P. S. and King, J.. (2011) Natalizumab treatment for multiple sclerosis : updated recommendations for patient selection and monitoring. The Lancet neurology, Vol. 10, H. 8. pp. 745-758.

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Official URL: http://edoc.unibas.ch/dok/A6338492

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Abstract

Natalizumab, a highly specific alpha4-integrin antagonist, is approved for treatment of patients with active relapsing-remitting multiple sclerosis (RRMS). It is generally recommended for individuals who have not responded to a currently available first-line disease-modifying therapy or who have very active disease. The expected benefits of natalizumab treatment have to be weighed against risks, especially the rare but serious adverse event of progressive multifocal leukoencephalopathy. In this Review, we revisit and update previous recommendations on natalizumab for treatment of patients with RRMS, based on additional long-term follow-up of clinical studies and post-marketing observations, including appropriate patient selection and management recommendations.

Faculties and Departments:	03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Neuroimmunology (Derfuss/Lindberg) 03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Transplantation Virology (Hirsch)
UniBasel Contributors:	Hirsch, Hans H. and Kappos, Ludwig
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Elsevier
ISSN:	1474-4465
Note:	Publication type according to Uni Basel Research Database: Journal article
Related URLs:	Document Document
Identification Number:	pmid: 21777829 doi: 10.1016/s1474-4422(11)70149-1
Last Modified:	10 Apr 2015 09:14
Deposited On:	10 Apr 2015 09:14

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