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Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors

Lambert, S. and Arras, M. and Vogt, K. E. and Rudolph, U.. (2005) Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors. European Journal of Pharmacology, Vol. 516, H. 1. pp. 23-27.

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Official URL: http://edoc.unibas.ch/dok/A5259782

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Abstract

The targets which mediate the actions of the volatile general anaesthetic isoflurane are unknown. Based on pharmacological studies using GABA(A) receptor antagonists it has recently been suggested that GABA(A) receptors would not mediate the immobilizing action of isoflurane. Using the beta3(N265M) knock-in mouse model we found that the mutant mice were less sensitive to the immobilizing action of isoflurane, indicating a role of beta3-containing GABA(A) receptors in mediating immobility. At high concentrations isoflurane also immobilizes beta3(N265M) mice, indicating that other targets also mediate immobility. Thus, our findings support a multisite model for the immobilizing action of isoflurane.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Vogt)
UniBasel Contributors:Vogt, Kaspar
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier Biomedical Press
ISSN:0014-2999
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:23

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