edoc

Apathy in Parkinson's disease is related to executive function, gender and age but not to depression

Meyer, Antonia and Zimmermann, Ronan and Gschwandtner, Ute and Hatz, Florian and Bousleiman, Habib and Schwarz, Nadine and Fuhr, Peter. (2014) Apathy in Parkinson's disease is related to executive function, gender and age but not to depression. Frontiers in aging neuroscience, Vol. 6 , 350.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6357811

Downloads: Statistics Overview

Abstract

Deficits in executive functions occur in up to 93% of patients with Parkinson's disease (PD). Apathy, a reduction of motivation and goal-directed behavior is an important part of the syndrome; affecting both the patients as well as their social environment. Executive functions can be subdivided into three different processes: initiation, shifting and inhibition. We examined the hypotheses, (1) that apathy in patients with Parkinson's disease is only related to initiation and not to shifting and inhibition, and (2) that depression and severity of motor signs correlate with apathy. Fifty-one non-demented patients (19 = female) with PD were evaluated for apathy, depression and executive functions. Executive function variables were summarized with an index variable according to the defined executive processes. Linear regression with stepwise elimination procedure was used to select significant predictors. The significant model (R (2) = 0.41; p > 0.01) revealed influences of initiation (b = -0.79; p > 0.01), gender (b = -7.75; p > 0.01), age (b = -0.07; p > 0.05) and an age by gender interaction (b = 0.12; p > 0.01) on apathy in Parkinson's disease. Motor signs, depression and level of education did not influence the relation. These results support an association of apathy and deficits of executive function in PD. Initiation strongly correlates with apathy, whereas depression does not. We conclude, that initiation dysfunction in a patient with Parkinson's disease heralds apathy. Apathy and depression can be dissociated. Additionally, apathy is influenced by age and gender: older age correlates with apathy in men, whereas in women it seems to protect against it.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics Frequentist Modelling
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Bou Sleiman, Habib
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Frontiers Research Foundation]
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:04 Sep 2015 14:32
Deposited On:10 Apr 2015 09:12

Repository Staff Only: item control page