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Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection

Cosgrove, C. and Ussher, J. E. and Rauch, A. and Gartner, K. and Kurioka, A. and Huhn, M. H. and Adelmann, K. and Kang, Y. H. and Fergusson, J. R. and Simmonds, P. and Goulder, P. and Hansen, T. H. and Fox, J. and Gunthard, H. F. and Khanna, N. and Powrie, F. and Steel, A. and Gazzard, B. and Phillips, R. E. and Frater, J. and Uhlig, H. and Klenerman, P.. (2013) Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood, Vol. 121, H. 6. pp. 951-961.

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Official URL: http://edoc.unibas.ch/dok/A6338416

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Abstract

HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161++ CD8+ T cells are a tissue-infiltrating population that produce IL17A, IL22, IFN, and TNFalpha, cytokines important in mucosal immunity. In adults they dominantly express the semi-invariant TCR Valpha7.2, the canonical feature of mucosal associated invariant T (MAIT) cells and have been recently implicated in host defense against pathogens. We analyzed the frequency and function of CD161++ /MAIT cells in peripheral blood and tissue from patients with early stage or chronic-stage HIV infection. We show that the CD161++ /MAIT cell population is significantly decreased in early HIV infection and fails to recover despite otherwise successful treatment. We provide evidence that CD161++ /MAIT cells are not preferentially infected but may be depleted through diverse mechanisms including accumulation in tissues and activation-induced cell death. This loss may impact mucosal defense and could be important in susceptibility to specific opportunistic infections in HIV.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
UniBasel Contributors:Khanna, Nina
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Society of Hematology
ISSN:1528-0020
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2015 09:12
Deposited On:10 Apr 2015 09:12

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