Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans : lost in translation

Hysek, C. M. and Schmid, Y. and Rickli, A. and Liechti, M. E.. (2013) Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans : lost in translation. British journal of pharmacology, 170 (6). pp. 1273-1275.

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Official URL: http://edoc.unibas.ch/dok/A6338346

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We greatly appreciate the comments offered by Drs Rolle, Takematsu, and Hoffman and the opportunity to put our work into a wider perspective. We share the view that our work does not reflect the clinical situation but rather provides a proof of mechanism study, which aims to help to translate preclinical findings (Sprague et al., 2005) into the clinic. As we noted in the discussion of our work (Hysek et al., 2012b) the primary goal of the study was to investigate the role of adrenoceptors in the mechanism of action of MDMA in humans. Therefore, the study provided only indirect support for the use of carvedilol in the treatment of stimulant toxicity in which carvedilol would be administered following the ingestion of Ecstasy or other stimulants. Furthermore, we noted the limitation that the MDMA-induced increase in body temperature in our study was moderate and we do not know whether carvedilol would also be effective in cases of severe hyperthermia following ecstasy use.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Psychopharmacology Research (Liechti)
UniBasel Contributors:Liechti, Matthias Emanuel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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edoc DOI:
Last Modified:30 Aug 2016 06:36
Deposited On:10 Apr 2015 09:12

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