Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic

Poteryaev, D. and Fares, H. and Bowerman, B. and Spang, A.. (2007) Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. The EMBO Journal, 26 (2). pp. 301-312.

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Official URL: http://edoc.unibas.ch/dok/A5259741

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The small rab-GTPase RAB-7 acts in endosome and endosome to lysosome traffic. We identified SAND-1 as a protein required for RAB-7 function based on similarities between SAND-1 and RAB-7 RNAi phenotypes. Although the initial uptake of yolk protein in oocytes, or of soluble secreted (ss) GFP in coelomocytes, appeared normal, further transport along the endocytic traffic route was delayed in the absence of SAND-1 function, and yolk proteins failed to reach yolk granules efficiently. Moreover, in coelomocytes, ssGFP and BSA-Texas-Red were endocytosed but not transported to lysosomes. We show that SAND-1 is essential for RAB-7 function at the transition from early to late endosomes, but not for RAB-7 function at lysosomes.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Spang)
UniBasel Contributors:Spang, Anne
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Nov 2017 15:39
Deposited On:22 Mar 2012 13:23

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