Biomacromolecules as Ligands for Artificial Metalloenzymes

Hamels, Didier R. and Ward, Thomas R.. (2013) Biomacromolecules as Ligands for Artificial Metalloenzymes. In: Comprehensive Inorganic Chemistry II , 6: Homogeneous Catalytic Applications. pp. 737-761.

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Official URL: http://edoc.unibas.ch/dok/A6212081

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First coordination sphere interactions usually are involved in metal-catalyzed enantioselective transformations: a chiral ligand directly linked to the metal dictates the enantiomeric outcome of a given reaction. A novel concept has emerged in the past 30 years: achiral metal complexes are inserted into proteins or DNA and the resulting artificial metalloenzymes catalyze various enantioselective transformations. In these hybrid catalysts, enantioselection is achieved with the help of the second coordination sphere, that is, a subtle combination of secondary interactions between the biomolecular scaffold, the catalyst, and the substrate. This chapter discusses the design of artificial metalloenzymes and their use in homogeneous catalysis.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R.
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Note:Publication type according to Uni Basel Research Database: Book item
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Last Modified:03 May 2017 07:25
Deposited On:06 Mar 2015 07:44

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