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Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT : a prospective phase II study in two centers

Stern, M. and Passweg, J. R. and Meyer-Monard, S. and Esser, R. and Tonn, T. and Soerensen, J. and Paulussen, M. and Gratwohl, A. and Klingebiel, T. and Bader, P. and Tichelli, A. and Schwabe, D. and Koehl, U.. (2013) Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT : a prospective phase II study in two centers. Bone marrow transplantation, Vol. 48, H. 3. pp. 433-438.

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Official URL: http://edoc.unibas.ch/dok/A6338082

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Abstract

Adoptive immunotherapy with allogeneic purified natural killer (NK) cell products might exert graft-versus-tumor alloreactivity with little risk of GVHD. In a prospective phase II study in two centers, we administered purified NK cell products to high-risk patients treated with haploidentical T-cell-depleted SCT. Sixteen patients received a total of 29 NK cell infusions on days +3, +40 and +100 after transplantation. Median doses (and ranges) of infused NK- and T-cells per product were 1.21 (0.3-3.8) x 10(7)/kg and 0.03 (0.004-0.72) x 10(5)/kg, respectively. With a median follow-up of 5.8 years 4/16 patients are alive. Cause of death was relapse in five, GVHD in three, graft failure in three, and transplant related neurotoxicity in one patient. Four patients developed acute GVHD</=grade II, all receiving a total of </=0.5 x 10(5) T cells/kg. Compared with historical controls, NK cell infusions had no apparent effect on the rates of graft failure or relapse. Adoptive transfer of allogeneic NK cells is safe and feasible, but further studies are needed to determine the optimal dose and timing of NK cell therapy. Moreover, NK cell activation/expansion may be required to attain clinical benefit, while careful consideration must be given to the number of T cells infused.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Immunotherapy (Stern)
UniBasel Contributors:Stern, Martin Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:0268-3369
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Mar 2015 07:44
Deposited On:06 Mar 2015 07:44

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