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The nuclear pore complex : from molecular architecture to functional dynamics

Stoffler, D. and Fahrenkrog, B. and Aebi, U.. (1999) The nuclear pore complex : from molecular architecture to functional dynamics. Current opinion in cell biology, Vol. 11, H. 3. pp. 391-401.

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Official URL: http://edoc.unibas.ch/dok/A5259615

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Abstract

Toward dissecting the molecular composition and architecture of the nuclear pore complex (NPC), over the past 18 months novel nucleoporins and NPC subcomplexes were identified and characterized. The three-dimensional structure of isolated yeast NPCs was determined by electron cryomicroscopy. New specimen preparation and labeling protocols localized a number of nucleoporins and NPC subcomplexes within the three-dimensional architecture of the yeast NPC. Structural changes of native NPCs mediated by physiological effectors such as calcium or ATP were monitored by time-lapse atomic force microscopy, thus revealing a first glimpse of the NPC's functional dynamics.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Fahrenkrog)
UniBasel Contributors:Fahrenkrog, Birthe
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0955-0674
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:29 Jan 2016 09:18
Deposited On:22 Mar 2012 13:23

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