Catalytic Enantioselective Total Synthesis of (–)-Pyridovericin

Schmid, Fabian and Bernasconi, Maurizio and Jessen, Henning J. and Pfaltz, Andreas and Gademann, Karl. (2014) Catalytic Enantioselective Total Synthesis of (–)-Pyridovericin. Synthesis, 46 (07). pp. 864-870.

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Official URL: http://edoc.unibas.ch/dok/A6337611

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The first enantioselective catalytic total synthesis of (–)-pyridovericin is reported. The key steps involve a modified HWE reaction under aqueous conditions and an asymmetric iridium-catalyzed hydrogenation. This resulted in a highly modular and stereoselective approach that delivered the target natural product in high yield and stereoselectivity.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Synthetische organische Chemie (Pfaltz)
UniBasel Contributors:Pfaltz, Andreas and Gademann, Karl and Schmid, Fabian
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Georg Thieme
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Apr 2017 08:47
Deposited On:06 Feb 2015 09:59

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