edoc

GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors

Giachino, C. and Barz, M. and Tchorz, J. S. and Tome, M. and Gassmann, M. and Bischofberger, J. and Bettler, B. and Taylor, V.. (2014) GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. Development, Vol. 141, H. 1. pp. 83-90.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6338053

Downloads: Statistics Overview

Abstract

Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express metabotropic GABAB receptors. Pharmacological inhibition of GABAB receptors stimulated NSC proliferation and genetic deletion of GABAB1 receptor subunits increased NSC proliferation and differentiation of neuroblasts in vivo. Cell-specific conditional deletion of GABAB receptors supports a cell-autonomous role in newly generated cells. Our data indicate that signaling through GABAB receptors is an inhibitor of adult neurogenesis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Embryology and Stem Cell Biology (Taylor)
03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Cellular Neurophysiology (Bischofberger)
UniBasel Contributors:Taylor, Verdon and Bettler, Bernhard and Bischofberger, Josef
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Company of Biologists
ISSN:0950-1991
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:06 Feb 2015 09:59
Deposited On:06 Feb 2015 09:59

Repository Staff Only: item control page