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Getting across the nuclear pore complex : new insights into nucleocytoplasmic transport

Stoffler, D. and Schwarz-Herion, K. and Aebi, U. and Fahrenkrog, B.. (2006) Getting across the nuclear pore complex : new insights into nucleocytoplasmic transport. Canadian Journal of Physiology and Pharmacology, Vol. 84, H. 3-4. pp. 499-507.

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Official URL: http://edoc.unibas.ch/dok/A5259600

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Abstract

Small ions and molecules can traverse the nuclear pore complex (NPC) simply by diffusion, whereas larger proteins and RNAs require specific signals and factors that facilitate their passage through the NPC. Our understanding of the factors that participate and regulate nucleocytoplasmic transport has increased tremendously over the past years, whereas the actual translocation step through the NPC has remained largely unclear. Here, we present and discuss recent findings on the interaction between the NPC and transport receptors and provide new evidence that the NPC acts as a constrained diffusion pore for molecules and particles without retention signal and as an affinity gate for signal-bearing cargos.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Fahrenkrog)
UniBasel Contributors:Fahrenkrog, Birthe
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
ISSN:0008-4212
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:23

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