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Distinct Limb and Trunk Premotor Circuits Establish Laterality in the Spinal Cord

Goetz, Cyrill and Pivetta, Chiara and Arber, Silvia. (2015) Distinct Limb and Trunk Premotor Circuits Establish Laterality in the Spinal Cord. Neuron, Vol. 85, H. 1. pp. 131-144.

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Official URL: http://edoc.unibas.ch/dok/A6337740

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Abstract

Movement coordination between opposite body sides relies on neuronal circuits capable of controlling muscle contractions according to motor commands. Trunk and limb muscles engage in distinctly lateralized behaviors, yet how regulatory spinal circuitry differs is less clear. Here, we intersect virus technology and mouse genetics to unravel striking distribution differences of interneurons connected to functionally distinct motor neurons. We find that premotor interneurons conveying information to axial motor neurons reside in symmetrically balanced locations while mostly ipsilateral premotor interneurons synapse with limb-innervating motor neurons, especially those innervating more distal muscles. We show that observed distribution differences reflect specific premotor interneuron subpopulations defined by genetic and neurotransmitter identity. Synaptic input across the midline reaches axial motor neurons preferentially through commissural axon arborization, and to a lesser extent, through midline-crossing dendrites capturing contralateral synaptic input. Together, our findings provide insight into principles of circuit organization underlying weighted lateralization of movement.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Arber, Silvia and Götz, Cyrill and Pivetta, Chiara
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0896-6273
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Aug 2015 12:05
Deposited On:06 Feb 2015 09:59

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