Fei, Na and Häussinger, Daniel and Blümli, Seraina and Laventie, Benoît-Joseph and Bizzini, Lorenzo D. and Zimmermann, Kaspar and Jenal, Urs and Gillingham, Dennis. (2014) Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides. Chemical Communications, 50 (62). pp. 8499-8502.
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Abstract
We describe a simple method for the direct modification of nucleobases in cyclic purine dinucleotides, important signalling molecules in both prokaryotes and eukaryotes. The method tolerates all members of the cyclic dinucleotide family and could be used to modulate their function or introduce useful side-chains such as fluorophores and photo-crosslinking groups.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development 05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Jenal) 05 Faculty of Science > Departement Biozentrum > Growth & Development > Molecular Microbiology (Jenal) 05 Faculty of Science > Departement Biozentrum > Infection Biology 05 Faculty of Science > Departement Chemie > Chemie > Nuclear Magnetic Resonance (Häussinger) |
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| UniBasel Contributors: | Jenal, Urs and Laventie, Benoit-Joseph and Fei, Na and Blümli, Seraina and Delarue Bizzini, Lorenzo and Zimmermann, Kaspar and Gillingham, Dennis and Häussinger, Daniel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 0022-4936 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
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| edoc DOI: | |
| Last Modified: | 28 Nov 2016 15:00 |
| Deposited On: | 06 Feb 2015 09:58 |
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