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How to clear a pathogen during inflammation: switching from phagocytosis to macropinocytosis through coronin 1 phosphorylation

BoseDasgupta Somdeb, Pieters Jean. (2014) How to clear a pathogen during inflammation: switching from phagocytosis to macropinocytosis through coronin 1 phosphorylation. Inflammation and cell signaling, Vol. 1, Nr. 4 , e199.

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Official URL: http://edoc.unibas.ch/dok/A6328978

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Abstract

The processes that allow phagocytes to eliminate pathogenic microbes under inflammatory conditions remain incompletely understood. Recent work has implicated coronin 1 in the modulation of endocytic traffic upon macrophage activation. While in resting macrophages, uptake occurs largely through receptor-mediated phagocytosis, inflammatory stimuli such as interferon-and tumor necrosis factor-were found to activate macropinocytic uptake of cargo through phosphatidyl-3 kinase activation in a coronin 1-dependent manner. In this commentary we will briefly describe these recently published results, and discuss how this inducible pathway may serve to clear the inflammatory site from large amounts of infectious material and couple pathogen clearance to a proper activation of immune responses.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Smart Science & Technology LLC
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Feb 2015 09:58
Deposited On:06 Feb 2015 09:58

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