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Spatial and temporal distribution of soil-transmitted helminth infection in sub-Saharan Africa : a systematic review and geostatistical meta-analysis

Karagiannis-Voules, D. A. and Biedermann, P. and Ekpo, U. F. and Garba, A. and Langer, E. and Mathieu, E. and Midzi, P. and Mwinzi, P. and Polderman, A. M. and Raso, G. and Sacko, M. and Talla, I. and Tchuem Tchuenté, L. A. and Touré, S. and Winkler, M. S. and Utzinger, J. and Vounatsou, P.. (2015) Spatial and temporal distribution of soil-transmitted helminth infection in sub-Saharan Africa : a systematic review and geostatistical meta-analysis. The Lancet infectious diseases, Vol. 15, H. 1. pp. 74-84.

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Official URL: http://edoc.unibas.ch/dok/A6329158

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Abstract

BACKGROUND: Interest is growing in predictive risk mapping for neglected tropical diseases (NTDs), particularly to scale up preventive chemotherapy, surveillance, and elimination efforts. Soil-transmitted helminths (hookworm, Ascaris lumbricoides, and Trichuris trichiura) are the most widespread NTDs, but broad geographical analyses are scarce. We aimed to predict the spatial and temporal distribution of soil-transmitted helminth infections, including the number of infected people and treatment needs, across sub-Saharan Africa. METHODS: We systematically searched PubMed, Web of Knowledge, and African Journal Online from inception to Dec 31, 2013, without language restrictions, to identify georeferenced surveys. We extracted data from household surveys on sources of drinking water, sanitation, and women's level of education. Bayesian geostatistical models were used to align the data in space and estimate risk of with hookworm, A lumbricoides, and T trichiura over a grid of roughly 1 million pixels at a spatial resolution of 5?×?5 km. We calculated anthelmintic treatment needs on the basis of WHO guidelines (treatment of all school-aged children once per year where prevalence in this population is 20-50% or twice per year if prevalence is greater than 50%). FINDINGS: We identified 459 relevant survey reports that referenced 6040 unique locations. We estimate that the prevalence of hookworm, A lumbricoides, and T trichiura among school-aged children from 2000 onwards was 16·5%, 6·6%, and 4·4%. These estimates are between 52% and 74% lower than those in surveys done before 2000, and have become similar to values for the entire communities. We estimated that 126 million doses of anthelmintic treatments are required per year. INTERPRETATION: Patterns of soil-transmitted helminth infection in sub-Saharan Africa have changed and the prevalence of infection has declined substantially in this millennium, probably due to socioeconomic development and large-scale deworming programmes. The global control strategy should be reassessed, with emphasis given also to adults to progress towards local elimination. FUNDING: Swiss National Science Foundation and European Research Council.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Bayesian Modelling and Analysis (Vounatsou)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Health Impact Assessment (Utzinger)
UniBasel Contributors:Utzinger, Jürg and Winkler, Mirko S. and Vounatsou, Penelope
Item Type:Article, refereed
Article Subtype:Review Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1473-3099
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:06 Feb 2015 09:58
Deposited On:06 Feb 2015 09:58

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