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Consequences of genomic diversity in Mycobacterium tuberculosis

Coscolla, Mireia and Gagneux, Sebastien. (2014) Consequences of genomic diversity in Mycobacterium tuberculosis. Seminars in immunology, Vol. 26, H. 6. pp. 431-444.

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Official URL: http://edoc.unibas.ch/dok/A6329036

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Abstract

The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC), comprises seven phylogenetically distinct lineages associated with different geographical regions. Here we review the latest findings on the nature and amount of genomic diversity within and between MTBC lineages. We then review recent evidence for the effect of this genomic diversity on mycobacterial phenotypes measured experimentally and in clinical settings. We conclude that overall, the most geographically widespread Lineage 2 (includes Beijing) and Lineage 4 (also known as Euro-American) are more virulent than other lineages that are more geographically restricted. This increased virulence is associated with delayed or reduced pro-inflammatory host immune responses, greater severity of disease, and enhanced transmission. Future work should focus on the interaction between MTBC and human genetic diversity, as well as on the environmental factors that modulate these interactions.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Research (Gagneux)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Coscoll√°, Mireja and Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1096-3618
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:09 Jan 2015 09:25
Deposited On:09 Jan 2015 09:25

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