edoc

Fibroblast Growth Factor Signaling Affects Vascular Outgrowth and Is Required for the Maintenance of Blood Vessel Integrity

De Smet, Frederik and Tembuyser, Bieke and Lenard, Anna and Claes, Filip and Zhang, Jie and Michielsen, Christof and Van Schepdael, Ann and Herbert, Jean-Marc and Bono, Françoise and Affolter, Markus and Dewerchin, Mieke and Carmeliet, Peter. (2014) Fibroblast Growth Factor Signaling Affects Vascular Outgrowth and Is Required for the Maintenance of Blood Vessel Integrity. Chemistry & biology, Vol. 21, H. 10. pp. 1310-1317.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6298891

Downloads: Statistics Overview

Abstract

Angiogenesis contributes to the development of numerous disorders. Even though fibroblast growth factors (FGFs) were discovered as mediators of angiogenesis more than 30 years ago, their role in developmental angiogenesis still remains elusive. We use a recently described chemical probe, SSR128129E (SSR), that selectively inhibits the action of multiple FGF receptors (FGFRs), in combination with the zebrafish model to examine the role of FGF signaling in vascular development. We observe that while FGFR signaling is less important for vessel guidance, it affects vascular outgrowth and is especially required for the maintenance of blood vessel integrity by ensuring proper cell-cell junctions between endothelial cells. In conclusion, our work illustrates the power of a small molecule probe to reveal insights into blood vessel formation and stabilization and thus of broad interest to the vascular biology community.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell Biology (Affolter)
UniBasel Contributors:Affolter, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:1074-5521
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:09 Jan 2015 09:25
Deposited On:09 Jan 2015 09:25

Repository Staff Only: item control page