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HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites

Streatfield, P. Kim and Khan, Wasif A. and Bhuiya, Abbas and Hanifi, Syed M. A. and Alam, Nurul and Millogo, Ourohiré and Sié, Ali and Zabré, Pascal and Rossier, Clementine and Soura, Abdramane B. and Bonfoh, Bassirou and Kone, Siaka and Ngoran, Eliezer K. and Utzinger, Juerg and Abera, Semaw F. and Melaku, Yohannes A. and Weldearegawi, Berhe and Gomez, Pierre and Jasseh, Momodou and Ansah, Patrick and Azongo, Daniel and Kondayire, Felix and Oduro, Abraham and Amu, Alberta and Gyapong, Margaret and Kwarteng, Odette and Kant, Shashi and Pandav, Chandrakant S. and Rai, Sanjay K. and Juvekar, Sanjay and Muralidharan, Veena and Wahab, Abdul and Wilopo, Siswanto and Bauni, Evasius and Mochamah, George and Ndila, Carolyne and Williams, Thomas N. and Khagayi, Sammy and Laserson, Kayla F. and Nyaguara, Amek and Van Eijk, Anna M. and Ezeh, Alex and Kyobutungi, Catherine and Wamukoya, Marylene and Chihana, Menard and Crampin, Amelia and Price, Alison and Delaunay, Valérie and Diallo, Aldiouma and Douillot, Laetitia and Sokhna, Cheikh and Gómez-Olivé, F. Xavier and Mee, Paul and Tollman, Stephen M. and Herbst, Kobus and Mossong, Joël and Chuc, Nguyen T. K. and Arthur, Samuelina S. and Sankoh, Osman A. and Byass, Peter. (2014) HIV/AIDS-related mortality in Africa and Asia : evidence from INDEPTH health and demographic surveillance system sites. Global health action, Vol. 7 , 25370.

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Official URL: http://edoc.unibas.ch/dok/A6319290

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Abstract

As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the individual level. Systematic application of verbal autopsy (VA) methods in defined populations provides an opportunity to assess the mortality burden of the pandemic from individual data.; To present standardised comparisons of HIV/AIDS-related mortality at sites across Africa and Asia, including closely related causes of death such as pulmonary tuberculosis (PTB) and pneumonia.; Deaths related to HIV/AIDS were extracted from individual demographic and VA data from 22 INDEPTH sites across Africa and Asia. VA data were standardised to WHO 2012 standard causes of death assigned using the InterVA-4 model. Between-site comparisons of mortality rates were standardised using the INDEPTH 2013 standard population.; The dataset covered a total of 10,773 deaths attributed to HIV/AIDS, observed over 12,204,043 person-years. HIV/AIDS-related mortality fractions and mortality rates varied widely across Africa and Asia, with highest burdens in eastern and southern Africa, and lowest burdens in Asia. There was evidence of rapidly declining rates at the sites with the heaviest burdens. HIV/AIDS mortality was also strongly related to PTB mortality. On a country basis, there were strong similarities between HIV/AIDS mortality rates at INDEPTH sites and those derived from modelled estimates.; Measuring HIV/AIDS-related mortality continues to be a challenging issue, all the more so as anti-retroviral treatment programmes alleviate mortality risks. The congruence between these results and other estimates adds plausibility to both approaches. These data, covering some of the highest mortality observed during the pandemic, will be an important baseline for understanding the future decline of HIV/AIDS.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Health Impact Assessment (Utzinger)
UniBasel Contributors:Utzinger, Jürg
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Co-Action Publishing]
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Sep 2015 14:32
Deposited On:09 Jan 2015 09:24

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