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Early detection of subjects at risk for vascular remodelling : results from the Swiss population-based study SAPALDIA

Dratva, Julia and Caviezel, Seraina and Schaffner, Emmanuel and Zemp, Elisabeth and de Groot, Eric and Schmidt-Trucksäss, Arno and Bettschart, Robert and Saleh, Lanja and Turk, Alexander and Gaspoz, Jean-Michel and Carballo, David and Kuenzli, Nino and Probst-Hensch, Nicole. (2014) Early detection of subjects at risk for vascular remodelling : results from the Swiss population-based study SAPALDIA. Swiss Medical Weekly, 144. w14052.

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Official URL: http://edoc.unibas.ch/dok/A6319254

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Abstract

As the burden of cardiovascular disease (CVD) increases globally, its prevention and risk assessment becomes ever more important. We thus investigated the longitudinal association of the cardiovascular risk scores in the population-based cohort SAPALDIA with carotid intima media thickening (CIMT), an indicator of sub-clinical disease, and CVD incidence.; In 2,832 SAPALDIA participants, the Swiss and ESC heart risk score (AGLA, SCORE) were calculated based on 2001 data and CIMT was measured in 2010/11. We ran multi-level linear regression analyses between scores and CIMT, stratified for CVD status and gender, and logistic analyses for doctor-diagnosed CVD incidence. Path analyses investigated direct and indirect effects on CIMT.; AGLA and SCORE were positively associated with increasing CIMT in both healthy and CVD diagnosed subjects and men and women. Participants in highest risk categories showed a significant CIMT difference of <0.20 mm compared to the reference risk category (>1%), even larger in CVD healthy subjects and men. With increasing risk the odds of CVD incidence increased (Ref. >1%; 10 yr. risk AGLA <10% OR 2.1, <20% OR 3.7). Path analyses yield risk factors' direct and indirect effects through blood pressure.; The positive longitudinal association between risk estimations and CIMT confirms the use of risk scores in assessing individuals and populations at risk. Systolic blood pressure appears to be a main pathological mechanism, underscoring the importance of optimal blood pressure control and the importance of prevention strategies of risk factors, indirectly affecting CIMT through the haemodynamic pathway.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Probst Hensch, Nicole and Künzli, Nino and Dratva, Julia and Schaffner, Emmanuel and Zemp Stutz, Elisabeth
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:EMH Schweizerischer Arzteverlag
ISSN:1424-7860
e-ISSN:1424-3997
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:31 Aug 2017 07:18
Deposited On:09 Jan 2015 09:24

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